2022-07-06

Are You Proud To Be An American?

Ewan McGregor Replaced with Alec Guinness in the Star Wars Obi-Wan Kenobi Series

Ewan McGregor was chosen to play the young Obi-Wan Kenobi because he looked a little bit like Alec Guinness.

https://www.youtube.com/watch?v=ocL1Q0aPdOg

Great Reset - Wikipedia

three core components of the Great Reset: the first involves creating conditions for a "stakeholder economy"; the second component includes building in a more "resilient, equitable, and sustainable" way—based on environmental, social, and governance (ESG) metrics which would incorporate more green public infrastructure projects; the third component is to "harness the innovations of the Fourth Industrial Revolution" for public good.[2][3] In her keynote speech opening the dialogues, International Monetary Fund director Kristalina Georgieva listed three key aspects of the sustainable response: green growth, smarter growth, and fairer growth.[4][1]

At the launch event for the Great Reset, Prince Charles listed key areas for action, similar to those listed in his Sustainable Markets Initiative, introduced in January 2020. These included the re-invigoration of science, technology and innovation, a move towards net zero emissions globally, the introduction of carbon pricing, re-inventing longstanding incentive structures, rebalancing investments to include more (though not all) green investments, and encouraging green public infrastructure projects

Roger Scruton: Why Intellectuals are Mostly Left

2022-06-28

Re: Kenobi

On Tue, Jun 28, 2022 at 2:05 PM Larry wrote:

In the comments to this video I already wrote:

I am going to concede that Obi-Wan Kenobi has a ton of logical problems. The question is whether it is still entertaining? Most certainly.

There is no shortage of people criticizing this show.   The Critical Drinker goes all out:


As I have already stated, I think that this is a pretty entertaining Star Wars television series.  I think that it is good but not great.  Some of the "logical problems" boil down to the interpretation of events.  There are things unstated that would have had to happen offscreen for it all to make sense.  This makes part of it bad writing, but I'm pretty happy with the rest of it.

Best wishes,

John Coffey


2022-06-26

Americans Are Running Out of Water #Shorts

https://www.youtube.com/shorts/GKx8SPt6BPA

I don't know how much of an issue this really is.

10 Things That Are More Popular Than You Ever Realize

https://www.youtube.com/watch?v=FY3nCRKtBHo&t=434s

I find myself wondering why instant coffee isn't more popular?  It was very popular in the '60s and '70s.

I like decaf coffee, but I drink real coffee in the morning.  Having to make two different kinds in the coffee maker is more trouble than it is worth.

2022-06-18

The actual science of the "industrial seed oil" panic

I get frustrated with all the contradictory health information we hear regularly.  This video does a good job of talking about the science and the arguments on both sides.

https://www.youtube.com/watch?v=efTBLsv4yYs

Boosters and Covid

---------- Forwarded message ---------
From: Larry 

Dunn said hospitals in Utah have been "stable" until this week. The state dashboard reports a 27.3% increase in the seven-day average of COVID-19 hospitalizations, and a 35.3% jump in seven-day average cases in the ICU.

"The silver lining in this increase is that it's definitely not as steep," she said. "It's happening at a slower pace."

Dunn said the increase in cases could be from new Omicron subvariants and vaccination/booster shot immunity wearing off.

"We're starting to see that increase and with that, an increase in positivity," said Dunn. "So we're now seeing 25% to 30% positivity."

She said current positivity rates mirror similar peaks seen in early 2021 and beyond.

"The people-over-people method is up 625% since April 2," she explained. "The testing-over-testing method is up 850%."




Monologue: The Party Is Over | Real Time with Bill Maher (HBO)

2022-06-15

"2000 Mules"

I watched the Dinesh D'Sousa documentary "2000 Mules."  (https://2000mules.com/)   Although the 90-minute video is maybe 30 minutes longer than it needs to be, it does a very effective job of making the case that the 2020 election was stolen.

It is almost certain that President Biden won the popular vote.  However, Presidential elections aren't decided by the popular vote, but by the Electoral College.  Because certain "Battle Ground" states were very close, it would have only taken relatively small shifts in five key counties in those states to swing the election.  We have heard about some election weirdness in some of those counties, but none of it seemed like it was enough to claim widespread election fraud.

Apparently, there is geo-tracking data available on all of us that can be purchased.  An organization called "True The Vote", purchased this data, and claims to have found evidence of widespread "mules" who stuffed election drop boxes with votes.  They set a very high bar for what they consider to be "evidence".  We have cases of people visiting 30 drop boxes while going back and forth to "non-profit organizations."  There is no plausible reason for people to visit so many drop boxes.

Most of these drop boxes only existed because of COVID.

The documentary only has videos of about a half dozen people stuffing drop boxes with votes.  This is illegal even if the votes might have been legitimate.  Most of these people were wearing rubber gloves so as to not leave fingerprints.  They also took photographs of themselves dropping in votes, reportedly because that is how they got paid.  The documentary also has a couple of whistle-blowers who explained how the scheme worked.  One person's job was to pay the "mules."

Dinesh D'Sousa crunches the numbers, and even by the very high bar for "evidence" set by "True The Vote", the number of votes cast illegally easily would have been enough to sway the election.  He also goes into detail about the people who funded these "non-profit organizations."

The documentary also finds people in nursing homes who were too far gone to have voted but somehow voted anyway.  One lady in a nursing home said that she didn't want to vote but a nurse made her vote, which is also illegal to coerce someone into voting.

Although I am convinced, my opinion is very much dependent upon the idea that the documentary is telling the truth.  I have little reason to doubt it, but I can't rule out the possibility that someone is lying.


https://www.youtube.com/watch?v=hC_Ph4o9D30&list=PLQjQKfvegGtmvYFAgkIvC16DCh_oMWXF3&index=1

2022-06-10

Re: Google employee 100 trillion digits of pi

"Don't be evil."

How much climate change was caused by this calculation?  How many resources were wasted?

Calculating 100 trillion digits of PI is like asking how angels can dance on the head of a pin?  Twelve digits will get you to Mars.

On Fri, Jun 10, 2022 at 5:01 PM Larry wrote:

: Google has successfully calculated 100 trillion digits of π, setting a new world record in the process. This isn't the first time Google has topped the leaderboard. In 2019, the search giant became the first to use a commercial cloud service and solid state drives to set the Pi record at 31.4 trillion digits calculated.

A team from the University of Applied Sciences of the Grisons swiped the record last year, pushing the total up to 62.8 trillion decimal places.

Like before, Google used y-cruncher to perform calculations. This time around, the Compute Engine was configured with 128 vCPUs, 864 GB of RAM and 100 Gbps of egress bandwidth. For comparison, the 2019 calculation had just 16 Gbps of egress bandwidth.

The program ran for a total of 157 days, 23 hours, 31 minutes and 7.651 seconds, utilizing 43.5 PB of reads and 38.5 PB of writes in the process.




2022-06-07

Fwd: Studies on Mask usage

Correlation is not causality.  You could have more mask usage in higher-risk areas.

Previous studies showed some benefits from mask usage.  If there is no benefit, then we need to know that.  However, I think that there is a pretty good reason why everybody at the hospital is wearing masks.

---------- Forwarded message ---------
From: Larry 


If studies showed masks did not limit covid spread, that would be extremely frustrating. If they showed mask use increased covid spread, it would be horrendous.


2022-06-01

Alzheimer's discovery hints at drugs to stop cells frying "like eggs"

The work shows how protein clumps long associated with the condition can cause heat to build up and fry brain cells "like an egg," and more promisingly, demonstrated how drugs could be deployed to stop things from reaching harmful temperatures.

The breakthrough stems from the team's explorations in what's known as intracellular thermogenesis, an emerging field that centers on gauging temperature changes within cells. Advanced sensors have made such measurements possible, and the team is the first to apply it to the study of Alzheimer's disease, focusing their attention on one of the prime suspects in its onset known as amyloid-beta proteins.

The buildup of amyloid-beta proteins into toxic clumps is considered a key driver of the neurodegeneration associated with Alzheimer's disease, and they therefore receive considerable attention from scientists working to better understand the condition. The Cambridge team had been investigating links between intracellular thermogenesis and amyloid-beta aggregation, and these advanced new sensors provided the perfect tools to delve into the details.

"Thermogenesis has been associated with cellular stress, which may promote further aggregation," said Chyi Wei Chung, the study's first author. "We believe that when there's an imbalance in cells, like when the amyloid-beta concentration is slightly too high and it starts to accumulate, cellular temperatures increase."

Have the Boomers Pinched Their Children’s Futures?

https://www.youtube.com/watch?v=ZuXzvjBYW8A

The video is a bit long, but it highlights the problems with demographics and government spending, population expansion, the welfare state, and inflation.

Although the video is about England, it applies equally well to the United States.  Although England has a National Health Service which is unsustainable, around 60% of health care spending in the United States is funded by the government.  Regardless of which country you are in, the government is not going to have the money to keep all its promises.

These kinds of problems aren't unique to the United States and Great Britain.  It is happening everywhere.  China faces a demographic crisis because there aren't enough young people to support its aging population.

I was a little bit disappointed by his Climate Change views, calling it an emergency, but he points out that the next generation will have to produce 88% less carbon dioxide.  This is completely unfeasible.  A great many people are going to freeze in the wintertime.  Far more people die from cold than they do from heat.

Population increase has always been a concern of mine.  It puts pressure on finite resources and makes them more expensive.  The cost of housing has reached insane levels, as have the property taxes on those houses.

 

2022-05-31

Here's Why It's So Bloody Hard To Sit Down And Get Work Done

The rise of ‘bai lan’: why China’s frustrated youth are ready to ‘let it rot'

In recent days, this phrase – and more previously 'tang ping' (lying flat, 躺平), which means rejecting gruelling competition for a low desire life – gained popularity as severe competition and high social expectations prompted many young Chinese to give up on hard work.

But bai lan has a more worrying layer in the way it is being used by young people in China: to actively embrace a deteriorating situation, rather than trying to turn it around. It is close to other Chinese phrases, for example 'to smash a cracked pot' (破罐破摔) and 'dead pigs are not afraid of boiling water' (死猪不怕开水烫).

State media have taken note of this trend. "Why modern young Chinese like to 'bai lan'?" one recent article in official media outlet asked. "In fact, this is as a result of negative auto suggestion, repeatedly telling oneself I cannot make it… And this kind of mentality often leads people to adopt the 'bai lan' attitude."

But the reality is not quite as state media suggested, says Sal Hang, a 29-year-old creative industry professional in Beijing. He says that for his generation of young Chinese, this attitude of letting things rot is likely to be caused by a lack of social mobility and increased uncertainty in today's China.

"Unlike my parents' generation, young Chinese today have much bigger expectations, but there are many more uncertainties for us, too. For example, we cannot make any long-term plans for our lives anymore, because we do not know what is going to happen to us even five years down the road."

2022-05-30

People are leaving Hong Kong and here's where they're going

The FDA is investigating a Hepatitis A outbreak linked to organic strawberries sold at Walmart, Trader Joe's and other retailers

Tony Robbins Life Force Review - Regenexx

I just heard Tony Robbins on the Brian Kilmeade show promoting miracle cures and his book on this subject.

There are most likely things that we can do to improve our health and longevity.  Many of these are well known, like eating fewer calories and consuming healthier foods.  I'll be posting links concerning fish oil, omega fatty acids, and vitamin D.

I have heard some things about various types of medical research that may be promising.


"To recap, I have been getting bombarded by patients and colleagues who mostly have heard Tony Robbins being interviewed on social media about the new book. Hence, it was high time that I took a look for myself. As you can see, in my opinion, the five statements that Tony made in this interview can't be supported by the science behind regenerative medicine or what the FDA reports. From looking through the book, some of his statements are a bit more grounded and there are some super interesting technologies discussed. However, in my opinion, some of the claims in the book are as wild as the claims he makes in this interview.

The upshot? I'm sure Tony is a great personal transformation speaker and obviously, he has a passion for whatever he does. However, at this point, my concern is that my patients are seeing his interviews on social media, and in my opinion, they are getting wildly misinformed."

2022-05-28

Re: $9 dollar pill prevents age related memory loss

On Sat, May 28, 2022 at 12:52 PM Larry wrote:

This could be a long way from a viable treatment.  There could be side effects, but I welcome a chance to help people.

2022-05-24

I’m tired of winning (and it's awesome)

https://www.youtube.com/watch?v=zTZuD4fVutc

The next generation of AMD CPUs coming this year has a big boost in CPU power, but not a big boost in integrated graphics.  I've been wanting a powerful APU, which has a CPU and powerful graphics on the same chip, saving the cost of a separate graphics card, like the custom chips that are on the XBOX Series X and the Sony PlayStation 5.  

The current generation AMD 5950x is a beast of a processor and can play games, but its graphics capability is very low compared to the videogame systems.

However, the next generation of AMD APUs is not coming out till next year or maybe the 4th quarter of this year as laptop processors.  If I want a powerful CPU and reasonably powerful graphics then either I would have to buy a new CPU and a graphics card, or settle for an upcoming laptop processor.  I think that 2023 should bring me some good options, although I was hoping to upgrade this year. 

My 2017 iMac can play games better than I expected.  It has a low-end graphics card like what would be found in a laptop.  However, the CPU power is unimpressive.  I have the option of upgrading the processor to an i7-7700K, at a cost of $350 to $400, but I would still be a few years out of date.  The better option is to wait for the next generation.

2022-05-19

Two AIs talk about becoming human.


https://www.youtube.com/watch?v=jz78fSnBG0s

This exchange makes AI look smarter than it really is.  It is an AI designed to imitate human speech.  There isn't a deep understanding.

Generative Pre-trained Transformer 3 is an autoregressive language model that uses deep learning to produce human-like text. It is the third-generation language prediction model in the GPT-n series created by OpenAI, a San Francisco-based artificial intelligence research laboratory. 

2022-05-17

The 20th Century Transformation of U.S. Agriculture and Farm Policy

In the 20nth century, we went from 41% of the workforce being employed in agriculture to 1.9% of the workforce being employed in agriculture.  That is an amazing transformation.

https://www.ers.usda.gov/webdocs/publications/44197/13566_eib3_1_.pdf

Ramjet Propulsion and the Near Impossibility of Interstellar Travel

The Cycles of Revolutions in Our Midst › American Greatness

At a time of impending recession, runaway inflation, and climbing interest rates, universities are charging students thousands of dollars in increased tuition and fees to subsidize an unproductive diversity, equity, and inclusion industry. And like all good commissariats, the DEI apparatchiks produce no research, do no teaching, and bully and repress those who do.

Their chief legacy is the millions of opportunistic mediocrities emerging from the shadows to mouth wokester shibboleths about climate change, diversity, equity, and inclusion, identity politics, and transgenderism, while damning the customs, traditions, history, and values of a prior society that alone is responsible for their very affluence and leisure. 

The stuff of life—water storage for agriculture, gas and oil production for transportation and home livability, building materials for shelter, deterrent police to ensure safe streets, and competent medical officials and scientists—is now subordinated to ideological censure and audit. All that is not a sustainable proposition for a sophisticated but vulnerable multiracial democracy of 330 million. Nihilist ideology finally trickles down to shelves empty of baby formula, idled diesel semis, and parked cars left open to thieves in hopes they will merely steal rather than also vandalize. Boutique university theories turn deadly when any society is unhinged enough to adopt them.

So this cannibalistic woke revolution is no Wobbly mine take-over, no 1960s Woodstock, not even a Black Panther, Weatherman, or Symbionese Liberation Army violent spasm. Instead, wokeism is so institutionalized that, like the Soviet Party or the adherents of Mao's little red book, joining the virtue-signaling wokesters is seen as a smart career move. Going woke is a bully's paradise, an indemnity against a past ill-considered tweet or a future peccadillo. Indeed, it is quasi-religious groupthink proselytizing. 

The world is fragmenting and changing in all different directions. Unfortunately, contemporary America is offering no guidance. To the extent it seeks to lead and inspire, its current elite wish to take other nations and cultures down a nihilist pathway of self-loathing that few wish to follow.

2022-05-16

The dangers of the COVID-19 spike protein

The dangers of the spike protein.

"SARS-CoV-2 Spike Proteins Disrupt the Blood-Brain Barrier, Potentially Raising Risk of Neurological Damage in COVID-19 Patients"



"Recent publications provide new findings that may help decipher the pathogenesis of long-COVID. One paper reported perivascular inflammation in brains of deceased patients with COVID-19, while others showed that the spike protein could damage the endothelium in an animal model, that it could disrupt an in vitro model of the blood-brain barrier (BBB), and that it can cross the BBB resulting in perivascular inflammation. Moreover, the spike protein appears to share antigenic epitopes with human molecular chaperons resulting in autoimmunity and can activate toll-like receptors (TLRs), leading to release of inflammatory cytokines. Moreover, some antibodies produced against the spike protein may not be neutralizing, but may change its conformation rendering it more likely to bind to its receptor. As a result, one wonders whether the spike protein entering the brain or being expressed by brain cells could activate microglia, alone or together with inflammatory cytokines, since protective antibodies could not cross the BBB, leading to neuro-inflammation and contributing to long-COVID. Hence, there is urgent need to better understand the neurotoxic effects of the spike protein."

https://link.springer.com/article/10.1007/s12035-021-02696-0

"A lot of people think of it as a respiratory disease, but it's really a vascular disease," says Assistant Research Professor Uri Manor, who is co-senior author of the study. "That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings."

"If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,"

https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/

COVID-19 spike proteins may cause neurological issues

"Researchers from the University of Bristol have found that, in cells in a dish in the lab, the spike protein binds to cells called pericytes which line the small vessels of the heart. This binding triggers a cascade of changes which disrupt normal cell function, and can lead to the release of chemicals that cause inflammation. This happened even when the protein was no longer attached to the virus.

There is some previous evidence to suggest that following Covid-19 illness, the spike protein can remain in the bloodstream after the virus has gone and travel far from the site of infection. This research could help explain and ultimately treat some of the effects of severe Covid-19 infection, where levels of the virus are particularly high. "

https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-archive/2021/august/covid-19-spike-protein-binds-to-and-changes-cells-in-the-heart


 "while other papers showed that the spike protein by itself (without being part of the corona virus) can damage endothelial cells and disrupt the blood-brain barrier. These findings may be even more relevant to the pathogenesis of long-COVID syndrome that may affect as many as 50% of those infected with SARS-CoV-2. "


"Very recently, Tavassoly et al. proposed a view that seeded protein aggregation by SARS-CoV-2 could be attributed to long-term post-infection complications including neurodegeneration [4]. They suggested that SARS-CoV-2 spike protein S1 region binds to heparin and heparin binding proteins (HBPs) present in brain which are prone to self-assembly, aggregation, and fibrillation processes. They also showed that the peptide from S protein (S–CoV-peptide; ∼150 aa) has more aggregation formation propensity than the known aggregation-prone proteins, suggesting that this peptide is prone to act as functional amyloid and form toxic aggregates. Thus, the heparin binding and aggregation propensity of S1 protein has been suggested the ability of S1 to form amyloid and toxic aggregates that can act as seeds to aggregate many of the misfolded brain proteins and can ultimately leads to neurodegeneration. It has been suggested that SARS-CoV-2 infection invades the CNS by controlling protein synthesis machinery, disturbs endoplasmic reticulum and mitochondrial function and increases the accumulation of misfolded proteins, thereby activates protein aggregation, mitochondrial oxidative stress, apoptosis and neurodegeneration [3,5,10].

Interestingly, it has been shown that HSV-1 spike protein binds to heparin and increases the aggregation of amyloid β (Aβ42) peptides on its surface spikes [11]. This study suggests that the heparin-binding site of the spike protein might act as a binding site for Aβ42 peptides and thus could dock to the viral surface and catalyze aggregation of Aβ42. As the receptor binding domain (RBD) of SARS-CoV-2, which is located within the S1 subunit of spike glycoprotein has several heparin binding sites [[12], [13], [14]], the same mechanism of aggregation of neurodegeneration causing proteins such as Aβ, α-synuclein, tau, prions, and TDP-43 can be observed in COVID-19 infection in the brain."





The vaccine spike protein is different.


In actual fact, the two spike proteins behave very differently in the body. According to Health Feedback, the spike proteins generated by Covid-19 vaccines differ in three key ways to those attached to SARS-CoV-2. Firstly, in the case of the vaccines, the cells mostly break down the spike proteins into fragments. Secondly, the spike protein generated by a Covid-19 vaccine doesn't assemble into new viral particles, unlike the spike protein from SARS-CoV-2. Thirdly, the spike protein in Covid-19 vaccines is genetically modified to enhance the immune response and to stop it binding to cell receptors in the same way the SARS-CoV-2 spike protein would.


 

'Toxic' spike protein claims misinterpret vaccine study

"There is no spike protein in the vaccines first of all. The amounts that are made after the mRNA is injected are very small and it almost exclusively stays locally. It is nowhere near the amount he was talking about," Dr Ratner said.

US fact checking website Health Feedback, which uses experts to verify claims about health science, said Dr Bridle's statement "rests on the assumption that if the viral spike protein causes cardiovascular toxicity in COVID-19 patients, the spike protein produced in vaccinated people should be toxic as well".

However, Health Feedback said this assumption was incorrect: "While both mRNA vaccines and viral vector vaccines carry the instructions to produce the entire spike protein, the cells break down much of the protein into small fragments. Furthermore, unlike infection, the spike protein from COVID-19 vaccination doesn't get assembled into new viral particles."

Prof Munro told AAP FactCheck that mRNA vaccines were "proving to be incredibly effective and safe" in protecting both the recipients and others from COVID-19, backing up clinical trials which "consistently demonstrated an excellent safety profile".




Will spike proteins generated through COVID vaccines cause illnesses to spread in schools?



"Vaccine skeptics have seized on the study to cast doubt on the safety of vaccines. But a review of the study's findings shows that the concerns raised by vaccine doubters are much ado about nothing.

The Study

The vascular endothelium is an important player in the illness and death associated with COVID-19. The endothelium is a system of cells that line and protect the inside of blood vessels. SARS-CoV2 injures the endothelium leading to blood clots, heart attack, pulmonary embolism, and stroke. Despite the established link between COVID-19 and these cardiovascular complications, the mechanism by which they develop is unknown.

Researchers from Jiaotong University; the University of California, San Diego; and the Salk Institute used a pseudovirus coated with spike protein to investigate the effects of the viral protein on endothelial cells. Pseudoviruses – which were first developed over 50 years ago – contain the outer shell of the virus, but they lack the viral genes needed to reproduce.

Hamsters treated with the spike protein coated pseudovirus showed lung damage similar to that seen in humans infected with SARS-CoV2. When researchers added pseudovirus to cultured endothelial cells they found that the mitochondria inside the cells were injured. Since mitochondria are responsible for providing energy to cells, their dysfunction can cause cell death.

When isolated pulmonary arteries were exposed to the spike protein carrying pseudovirus there was some disruption in the ability of the blood vessels to dilate. The decreased ability to expand blood vessels that serve the lungs could impair the ability of the body to take up oxygen from lungs that are damaged by the virus.

The novelty of this study was the discovery that the spike protein itself causes damage, and that the pathway triggered by the spike protein could explain the widespread cardiovascular complications that develop in COVID-19 patients.

A Twisted Tale

Shortly after Lei and colleagues published their study, vaccine skeptics touted the findings as proof that newly developed COVID-19 vaccines are dangerous. Afterall, if COVID-19 vaccines produce spike protein to trigger immunity, and that same spike protein causes injury, then vaccines are really no different than the disease they are designed to prevent.

The problem with these claims is that science doesn't support their arguments.

The Long Road to Perdition....

In order to damage the endothelium of blood vessels, COVID-19 vaccines have to enter the vascular system and infect cells that circulate in the blood. Data collected by the European Medicines Agency shows that no significant amount of vaccine enters the circulation (3). The confinement of the expressed spike protein away from the circulatory system significant prevents it from causing damage to the vascular endothelium.


Redesigning the Spike Protein

The spike protein attaches SARS-CoV2 to cells through a receptor called ACE2. In order to fully interact, the spike protein must undergo a conformational change.

A research team lead by Dr. Barney Graham from the Vaccine Research Center at the NIH National Institute of Allergy and Infectious Diseases created an engineered form of the spike protein that is unable to make the shape change required to effectively bind to cells (5). The Pfizer/BioNTech, Moderna, Novavax, and Johnson & Johnson vaccines all use this inactivated spike protein, which means any spike protein that is produced by the vaccine is not able to be activated. This safety-switch limits the ability of the spike protein to bind ACE2 and limits its ability to cause damage.

Stuck in a Hole

In addition to engineering the spike protein so it can not be fully activated the protein is tagged with an extra piece called a "transmembrane anchor" (6). The transmembrane anchor allows the spike protein to appear on the surface – or membrane – of the cell, but it is held in place by the anchor. This prevents the spike protein from drifting away and creates a fixed target for the immune system to recognize the foreign protein."

https://covid19resources.ca/2021/05/13/the-thorny-problem-of-covid-19-vaccines-and-spike-proteins/

So far, there is no scientific evidence available that suggests that spike proteins created in our bodies from the COVID-19 vaccines are toxic or damaging our organs. COVID-19 vaccines are relatively new and long-term side effects are yet to be known. However, the vaccines have met the safety standards of many government and international safety agencies.

Several systems help us monitor vaccine safety. In the United States these include the Vaccine Adverse Event Reporting System (VAERS), The Vaccine Safety Datalink (VSD), the Post-License Rapid Immunization Safety Monitoring (PRISM), and the Clinical Immunization Safety Assessment Project (CISA). These systems are used by scientists to monitor side effects and any other patterns of risks from vaccines.

The COVID-19 vaccine has been administered to 135 million people in the United States. As expected with any vaccine, some fully vaccinated people still got sick, hospitalized, and/or died. These "breakthrough cases" are a very small percentage of those vaccinated (<0.001%) and are being studied to detect any relevant patterns.

So far no scientific evidence is available that gives credence to claims that spike proteins created from vaccines travel in our bloodstreams. Research shows that spike proteins stay stuck to the surface of the cells around the vaccine's injection site. They are not known to wander around to other parts of the body.

A very tiny dose of the vaccine does make it to the bloodstream (about 1%), but as soon as it gets to the liver, the enzymes there destroy it completely. The U.S. CDC refers to the spike protein made from the vaccine as "harmless."



But researchers and health officials told FactCheck.org there is no "mistake" and that there is no evidence to support Bridle's claims.

There is no evidence that the spike protein in vaccines "is toxic or that it lingers at any toxic level in the body after vaccination," an FDA spokesperson told us in an email.

Jason McLellan, a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for years and whose work was fundamental for the development of COVID-19 vaccines, said Bridle's statements are not correct.  

"The spike protein is not pathogenic. It is not a toxin," McLellan told us in an email. "I have not seen any data to support what Bridle claims."




How long does the mRNA vaccine stay in the body?
https://youtu.be/dTXnCcBHGDM?t=58

"The Pfizer and Moderna vaccines work by introducing mRNA (messenger RNA) into your muscle cells. The cells make copies of the spike protein and the mRNA is quickly degraded (within a few days). The cell breaks the mRNA up into small harmless pieces. mRNA is very fragile; that's one reason why mRNA vaccines must be so carefully preserved at very low temperatures."


Does the COVID-19 vaccine cause Prion disease?




Safety of the COVID-19 mRNA vaccines.

"The clinical trials for the Pfizer-BioNTech and Moderna vaccines found both to be safe overall. When serious side effects did occur, they happened at comparable rates between people who had received the vaccine and those who had received a placebo injection."


"Notably, the study identified 34 cases of heart inflammation in patients aged 12 to 39 years. 85% of these cases occurred in males. 82% of these people were hospitalized for a median of 1 day. The authors calculated that among patients aged 12 to 39 years, there is a slight risk of 6.3 additional myocarditis cases per million doses during the first week after vaccination.

However, a separate study recently published in the New England Journal of Medicine shows that heart inflammation events are far more likely after COVID-19 infection than vaccination."







"But because reinfection is possible and COVID-19 can cause severe medical complications, it's recommended that people who have already had COVID-19 get a COVID-19 vaccine. A recent study showed that unvaccinated people who already had COVID-19 are more than twice as likely as fully vaccinated people to be reinfected with COVID-19.

Recent research also suggests that people who got COVID-19 in 2020 and then received mRNA vaccines produce very high levels of antibodies that are likely effective against current and, possibly, future variants. Some scientists call this hybrid immunity."

2022-05-03

Violent 11-year-old girl is terrorizing unsuspecting people in Boston. Cops know all about her — but can't do much because of her age.

CNN guest's appearance goes viral as he delivers hysterical rant on the need to control unfettered free speech - TheBlaze

"This is dangerous!" he shouted. "We can't think anymore in this country — we don't have people ... in Congress who can make regulations that can make it work. I think we can look to the Western countries in Europe for how they are trying to limit it, but you need — you need — controls on this. You need regulation. You cannot let these guys control discourse in this country or we are headed to hell. We are there. Trump opened the gates of hell and now they're chasing us down."

2022-05-02

3 AWFUL Habits That Make People Instantly Dislike You

https://www.youtube.com/watch?v=0ZFNr44I4UI

I think that this advice can be summed up as you should make other people feel involved and appreciated.

I saw another video that claimed that the way you gain confidence is to practice.  This odd advice might not seem applicable to most things, but I think that it is.   I would not be confident making a speech or in an awkward social situation, but I am pretty confident over a chessboard.  However, if I had spent 47 years making speeches then I most likely would be reasonably competent at it. 

2022-04-29

Watch "The mathematics of weight loss | Ruben Meerman | TEDxQUT on YouTube

I was confusing this video with a similarly titled video that I saw years ago that claimed that the mathematics of weight loss was just calories out versus calories in.  Although technically true, weight loss is more complicated, with certain foods like sugar being worse than others.  Sugar actually stimulates appetite.   In addition, our gut flora send signals to our brain to stimulate our appetite for specific foods.  Those bacteria get hungry, and different bacteria prefer different types of nutrients.   Eating healthy foods adjusts your gut bacteria to that diet.

This is where probiotics might be helpful.




In addition, I just read about "obesogens", which at first sounded like a joke to me, which are chemicals in the environment that promote obesity.  https://www.ehn.org/chemicals-in-everyday-products-are-spurring-obesity-warns-a-new-review-2657191067.html

In terms of the chemistry of metabolism, this video is scientifically interesting.  However, it isn't really news that we lose mass as we breathe out carbon dioxide.


On Tue, Apr 26, 2022 at 5:07 AM Albert > wrote:
Hands down the best scientific explanation of weight loss. The bottomline: eat less and move more.



2022-04-23

Shanghai Locks Workers in Factories Amid Covid Scare

Study reveals some brain changes, even in mild COVID-19 | CIDRAP

The study authors noted that the imaging differences between the two groups were modest, at about 2% of average baseline values. The typical annual loss of gray matter each year due to aging, the researchers said, is 0.2% to 0.3%.

Cognitive tests identified differences between COVID-19 survivors and controls, including a significant increase in the time taken to complete Trails A (numeric; 7.8%) and B (alphanumeric; 12.2%) of the Trail Making Test in COVID-19 participants. These results held true when excluding the 15 hospitalized patients (Trail A, 6.5%; Trail B, 12.5%).

"The infected participants also showed on average larger cognitive decline between the two timepoints," the study authors wrote. "Importantly, these imaging and cognitive longitudinal effects were still seen after excluding the 15 cases who had been hospitalised."

Not all COVID survivors have brain changes

In addition to the modest COVID-19 effect, the study authors noted that the statistics represent an average effect, meaning that not every COVID-19 survivor will experience brain changes.

2022-04-19

What If You Never Turn Off Your Computer?

Canada & The United States's Bizarre Border

Climate Change Is NOT An Emergency — Here Are The Facts

It missed us by 9 days

Fearing US Will OVERTHROW the Regime, China’s Communist Party Begins Nuclear Buildup

Opinion | What I wish I’d known when I was 19 and had sex reassignment surgery

I may well have transitioned even after waiting a few years. If I hadn't transitioned, I likely would have suffered from the world in other ways. In other words, I'm still working out how much regret to feel, but I'm comfortable with the ambiguity.

What advice would I pass on to young people seeking transition? Learning to fit in your body is a common struggle. Fad diets, body-shaping clothing and cosmetic surgery are all signs that countless millions of people at some point have a hard time accepting their own reflection. The prospect of sex can be intimidating. But sex is essential in healthy relationships. Give it a chance before permanently altering your body.

Most of all, slow down. You may yet decide to make the change. But if you explore the world by inhabiting your body as it is, perhaps you'll find that you love it more than you thought possible.

2022-03-25

Its all a Scam! - Before Replacing Your Phone Battery Watch This

Chinese Agents Are Hunting Down Dissidents in America

A Really Really Old Man

Covid booster restores vaccine protection lost against omicron variant, U.K. study finds

High chance of new COVID variant that's worse that Omicron in 2024, says UK CMO

European wave of Omicron sub-variant BA.2 foreshadows US surge | Financial Times

COVID-19 vaccine prior to infection may reduce long COVID symptoms

2022-03-19

COVID update

It is helpful to see where we are at.  

We have gone from 1 out of 11 people being infected to roughly 1 out of 15.  Still, that seems high to me.  The number of new cases is surprisingly low.  The number of deaths is approaching a million, but the daily deaths have dropped quite a bit.

I think that we got lucky with the Omicron variant.  I've been saying that it is like a different disease because it has slightly different symptoms.  Reportedly it is ten times more infectious but ten times less deadly.  It is like comparing cowpox to smallpox, where cowpox acts as a natural vaccine to smallpox.

This video is predicting a surge of the BA 2 variant...






--

2022-03-18

Fwd: Overwhelmed by Omicron, Hong Kong Runs Out of Space for Its Dead - The Wall Street Journal

FYI

---------- Forwarded message ---------
From: Albert 
Date: Fri, Mar 18, 2022 at 1:31 PM

It's not over until it's over. We should be cautious about putting our guard down on covid. Mainstream news has been avoiding covid stories because the Russo-Ukraine War brings more viewers and clicks. Nevertheless, as you and I know, the covid story will continue long after the Russo-Ukraine War is over.

Overwhelmed by Omicron, Hong Kong Runs Out of Space for Its Dead - The Wall Street Journal

https://apple.news/A4yDI5zQhTHKEqEV1zU4dkw

--

Fwd: Most Satisfying Factory Machines and Ingenious Tools

This video is interesting, more toward the beginning.

2022-03-09

The Pfizer documents. Adverse effects and death


Normally I have been a fan of Dr. John Campbell's videos, but here he takes a more anti-Pfizer vaccine position with a conspiracy theory tone.  I'm kind of disappointed because I took him to be a reliable source of information.

In response to his video, I wrote the following comment:

It is irresponsible to say that the 1,223 deaths were due to vaccination. Reportedly, anyone can submit an adverse event whether it was caused by the vaccine or not. Two out of every 100,000 vaccinated people got myocarditis, but 20 to 30% of the people hospitalized with COVID-19 developed heart problems.

The purpose of the adverse event reporting system is to determine if adverse events occur beyond what would be normal.    During the vaccine trial, 6 people died, mostly from cardiac events, and 4 of those deaths came from the placebo group.  https://www.reuters.com/article/uk-factcheck-pfizer-health-concerns/fact-check-clarifying-claims-around-pfizer-vaccine-deaths-and-side-effects-idUSKBN28K2R6

However, let us take the 1,223 death number at face value for a moment.  From what I can tell, by the end of February 2021, 20% of American adults were vaccinated. That's around 51 million people, mostly older people from which we could expect some deaths regardless.  If 1,223 died from vaccination, then that is 1 out of 41,700.  However, the risk from COVID is greater with 1 out of 333 Americans dying from the disease.

It appeared as if my comment to the video was posted and then deleted within seconds.  I don't understand this unless some automatic filter is eliminating my comment.  I tried a couple of more times and got the same result.










How the Doughnut got its Hole

Man given genetically modified pig heart dies - BBC News

2022-03-08

Even Mild Cases of COVID Can Cause Brain Damage and Shrinkage

Those who had COVID-19 had significantly more brain tissue loss and shrinkage, the researchers found. People typically lose around 0.2-0.3% of gray matter each year with normal aging, and those who had COVID-19 were losing far more, up to 2%. They also lost more overall brain volume and had higher amounts of tissue damage.

The damage was equivalent to at least an extra year of aging, Gwenaëlle Douaud, an associate professor at the Nuffield Department of Clinical Neurosciences at Oxford and the paper's lead author, told NBC News.

"It is brain damage, but it is possible that it is reversible," she said. "But it is still relatively scary because it was in mildly infected people."

https://people.com/health/even-mild-cases-of-covid-can-cause-brain-damage-and-shrinkage-study-finds/

This is like the mother of all diseases.

Indiana cracking down on drivers

I heard on the news that the State of Indiana is spending millions to have extra traffic enforcement until March 21st.  Be that good or bad, it is not a good time to be speeding.  I'm going to be more careful.

I find this odd since there doesn't seem to be much enforcement on 465.  If you are not driving ten miles over the speed limit, then everybody passes you. 

--

Ivermectin, more evidence


I'm neutral on this.  It might take more studies to verify this.  Too many times we have seen the results of studies that were refuted later.

Re: A troubling trend in lighting?

A couple of years ago my step-dad and I went to Lowes to get an outdoor light fixture.  The person who helped us tried to sell us a fixture that did not have a replaceable bulb, which means that when the fixture burns out you have to replace the entire fixture.   I chose to get one with a bulb socket instead, which has to be much easier in the long run.  Everybody knows how to replace a light bulb.

With my stepdad's help, it wasn't hard to install, which means that people should be capable of replacing their light fixtures.  The biggest problem was reaching it with a ladder.  However, how many people are going to accidentally electrocute themselves, start a fire, or fall off a ladder trying to replace the entire fixture?


On Mon, Mar 7, 2022 at 8:29 PM Al wrote:
Everything and more I wanted to know about LED lighting. Good video.

On Sun, Mar 6, 2022 at 10:21 PM John Coffey wrote: